A spatial weights matrix quantifies the spatial relationships that exist among the features in your dataset. Many tools in the Spatial Statistics toolbox evaluate each feature within the context of its neighboring features. The spatial weights matrix file defines those neighbor spatial relationships. (For more information about spatial weights and spatial weights matrix files, see Spatial weights.)
Typically, spatial relationships among a set of features are defined using Euclidean distance measurements and contiguity, fixed, or inverse distance weighting schemes (see Modeling spatial relationships). However, for many applications, including retail analysis, accessibility to services, emergency response, evacuation planning, and traffic incident analyses, defining spatial relationships in terms of real-world travel networks (roads, railways, footpaths, for example) is more appropriate. The Generate Network Spatial Weights tool allows you to model and store spatial relationships based on time or distance between point features in the case where travel is restricted to a network dataset. This tool requires a license for the ArcGIS Network Analyst extension.
You provide a point feature class representing both feature origins and feature destinations. You also provide an existing network dataset (see Designing a network dataset or use one of the ready-to-use network datasets that come with Street Map Premium for ArcGIS). The Generate Network Spatial Weights tool locates each point on the network and quantifies, in distance or time, the proximity between each and every other feature. The resultant proximity solution for any two features may optionally consider barriers and/or restrictions (road closures, for example). These proximity values are utilized in the mathematics of several spatial statistics tools including Spatial Autocorrelation (Global Moran's I), Hot Spot Analysis (Getis-Ord Gi*), and Cluster and Outlier Analysis (Anselin Local Moran's I).
Additional resources
Anselin, L. (1988). Spatial Econometrics: Methods and Models. Boston: Kluwer.
Getis, A., and Aldstadt, J. (2004). "Constructing the Spatial Weights Matrix Using a Local Statistic." Geographical Analysis 36(2):90–104.
Haining, R. (2003). Spatial Data Analysis: Theory and Practice. Cambridge, UK: Cambridge University Press.
Price, Mike. (Fall 2009). "It's all about streets". ArcUser Online. ESRI.